{"id":39882,"date":"2020-06-03T09:30:38","date_gmt":"2020-06-03T04:00:38","guid":{"rendered":"https:\/\/allgujaratnews.in\/?p=39882"},"modified":"2020-06-03T07:49:14","modified_gmt":"2020-06-03T02:19:14","slug":"this-re-purpose-drug-might-fight-against-corona","status":"publish","type":"post","link":"https:\/\/allgujaratnews.in\/en\/this-re-purpose-drug-might-fight-against-corona\/","title":{"rendered":"This re-purpose drug might fight against corona"},"content":{"rendered":"<p>The Science and Engineering Research Board has approved support for research at IIT (BHU) Varanasi to identify lead compound(s) from available and approved drugs for fast-track anti-SARS-CoV-2 drug molecule.<\/p>\n<p>Scientists and healthcare professionals over the world are trying for a cure for the pandemic, which afflicts the world today. At present, available treatments are focused only on symptomatic relief to help the patient overcome the infection.<\/p>\n<p>Repurposing of pre-existing drugs could help circumvent both the time and money required to find an effective cure.<\/p>\n<p>The research group of Prof. Vikash Kumar Dubey is working on developing new drug candidates against SARS-CoV-2 by exploring DrugBank (DrugBank is a database of FDA approved drug compounds.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-39886\" src=\"https:\/\/i1.wp.com\/allgujaratnews.in\/wp-content\/uploads\/2020\/06\/Corona-Drug.jpg?resize=351%2C247&#038;ssl=1\" alt=\"\" width=\"351\" height=\"247\" data-recalc-dims=\"1\" \/><\/p>\n<p>This database will be used for searching drug against SARS-CoV-2) database compounds as an inhibitor of SARS-CoV-2 main protease, a key enzyme required for SARS-CoV-2 assembly and multiplication. They will be carrying out extensive computational and experimental studies to identify an inhibitor of SARS-CoV-2 main protease.<\/p>\n<p>Taking advantage of available crystal structure of the SARS-CoV-2 main protease, a structure-based inhibitor design will be done by the researchers from the available FDA approved drugs compounds in the DrugBank database.<\/p>\n<p>Subsequently, experimental validation of the designed inhibitor(s) on recombinant SARS-CoV-2 Mpro Protein will be carried out. Various inhibitor parameters will be calculated to establish the effectiveness of the inhibition of the SARS-CoV-2 Mpro enzyme function.<\/p>\n<p>As the enzyme SARS-CoV-2 Mpro, is key for processing and polyprotein for virus assembly, the inhibition of this key protein can have an anti-viral effect. As most of DrugBank database compounds are characterized in terms of pharmacokinetics and toxicity, the identified molecule could be brought to the market rapidly.<\/p>","protected":false},"excerpt":{"rendered":"<p>The Science and Engineering Research Board has approved support for research at IIT (BHU) Varanasi to identify lead compound(s) from available and approved drugs for fast-track anti-SARS-CoV-2 drug molecule. Scientists and healthcare professionals over the world are trying for a cure for the pandemic, which afflicts the world today. At present, available treatments are focused [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","spay_email":"","footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[7791],"tags":[5978,8632,4821,6992,4935,7792,115],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_shortlink":"https:\/\/wp.me\/paUKPQ-ang","_links":{"self":[{"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/posts\/39882"}],"collection":[{"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/comments?post=39882"}],"version-history":[{"count":1,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/posts\/39882\/revisions"}],"predecessor-version":[{"id":39888,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/posts\/39882\/revisions\/39888"}],"wp:attachment":[{"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/media?parent=39882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/categories?post=39882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/allgujaratnews.in\/en\/wp-json\/wp\/v2\/tags?post=39882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}